AI-guided peptide design
Unlocking the Full Therapeutic Potential of Peptides
We are building a platform to advance promising peptide therapeutics, design entirely new molecules, and help partners address longstanding barriers to clinical development.
Our vision
Peptides are among nature’s most extraordinary molecules.
Peptaris is building an AI-powered platform to design peptides with the properties they need to become viable medicines.
Balance Multiple Properties at Once
We generate optimized candidates with targeted functional and developability properties.
Laboratory Data Generation
Our high-quality synthesis and experimental data libraries are architected for reliable model training.
A Continuous Learning System
The sophistication and accuracy of our molecular designs compound with every cycle.
The opportunity
The Next Frontier in Peptide Therapeutics
Peptides are among biology’s most versatile molecules, playing essential roles in many of the body’s most important functions. They have already given rise to important medicines, yet much of their therapeutic potential remains unrealized.
Many promising peptides are unstable, short-lived, or difficult to deliver effectively. Advances in artificial intelligence and medicinal chemistry are creating new opportunities to overcome these challenges and expand what peptides can achieve.
Advancing Promising Peptides
Addressing the properties that have limited the development of biologically promising peptides, helping move them closer to viable therapeutic compounds.
Reimagining Existing Successes
Engineering known peptides to achieve a more balanced set of pharmacological properties and create novel molecular designs.
Designing New Molecules
Exploring entirely new peptide designs with combinatorial chemistry to expand possibilities.
Lineage
Each generation of peptide medicine solved one more problem.
The next one has to solve many at once.
- GEN.01
Natural peptides
Hormones and host-defence peptides evolved for function, not for stability or delivery.
insulin · oxytocin · AMPs
- GEN.02
Engineered analogues
Medicinal chemistry tunes one property at a time: half-life, potency, or selectivity.
octreotide · desmopressin
- GEN.03
Modern peptide therapeutics
Lipidation and backbone changes produce blockbuster medicines, proving what peptides can do.
GLP-1 receptor agonists
- GEN.04
AI-designed peptides
Models trained on purpose-built lab data balance many functional and developability properties at once.
Peptaris
Our approach
A New Era of Peptide Design
Peptaris is building an AI-powered platform to design peptides with the properties they need to become viable medicines.
Our foundation
Built on Pioneering Science
Peptaris was founded by scientists from the University of Pennsylvania’s Machine Biology Group and entrepreneurs with a shared ambition to advance the field of peptide design.
Building on research in AI-guided peptide discovery, our team brings together expertise in predicting how peptide sequences influence biological activity and engineering molecules with improved therapeutic properties.
Our ambition is to translate advances in molecular design and medicinal chemistry into the next generation of peptide medicines.
In the news
News & Insights
Discover the latest news from Peptaris and the pioneering research of our scientific founders.
Blog ·
Introducing Peptaris
Why we started a company to unlock the full therapeutic potential of peptides, and what we are building in Philadelphia.
1 min read
Company news / Penn OCINO
Penn's StartUP Fund Announces its First Investments (opens in a new tab)
Founders in the news / OpenAI
Accelerating antibiotic discovery with ChatGPT (opens in a new tab)
Careers
Join Our Team
We are building an interdisciplinary team of scientists and engineers to advance the next generation of peptide design.
Join us at the intersection of artificial intelligence, chemistry, and biology, where ambitious ideas become scientific breakthroughs.
FAQ
Frequently asked questions
What does Peptaris do?
Peptaris is building an AI-powered platform to design peptides with the properties they need to become viable medicines: advancing promising peptides, reimagining existing successes, and designing entirely new molecules.
Why peptides?
Peptides are among biology's most versatile molecules and have already given rise to important medicines. Many promising peptides, however, are unstable, short-lived, or difficult to deliver. Advances in AI and medicinal chemistry are creating new opportunities to overcome these challenges.
How is the platform different?
We optimize multiple functional and developability properties at once, generate our own high-quality laboratory data architected for model training, and run a continuous learning loop in which every design cycle improves the next.
Are the publications on this site studies conducted by Peptaris?
No. The publications we list describe academic research and collaborative contributions from our scientific founders and their collaborators. They inform our scientific foundations but are not evidence of the current performance of our commercial platform.
How can we partner with Peptaris?
We collaborate on existing and emerging therapeutic programs. Write to info@peptaris.com and tell us about your program.
Partnerships